Quantifying immune receptor diversity

Event Date: 

Tuesday, December 4, 2012 - 4:00pm

Event Location: 

  • Broida 1640

Event Contact: 

Refreshments served at 3:40

Speaker:

Aleksandra Walzcak - LPTHE, Ecole Normale Sperieure

Recognition of pathogens relies on the diversity of immune receptor proteins. Recent experiments that sequence the entire immune cell repertoires provide a new opportunity for quantitative insight into naturally occurring diversity and how it is generated.  The generation process is implemented via a series of stochastic molecular events involving gene choices and random nucleotide insertions between, and deletions from, genes. I will describe how we can attempt to quantify the diversity of the receptors formed in this process and point to the origins of diversity in these sequences.