In my career, I have focused on designing and building novel particle detectors and then using those detectors to search for new phenomena. The physics topics I have investigated include the lifetime and time evolution of the bottom, strange, and charm quarks, including matter-antimatter asymmetries, in experiments at SLAC, CERN, and Cornell. For the past 2 decades, I have focused on seeking signals from dark matter with detectors deployed in underground laboratories, including those at Stanford, Soudan, Minnesota, and SURF in South Dakota, using the CDMS, LUX, and LZ experiments.